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Table 2 Average velocity of heterochromatin protein 1β (HP1β), B lymphoma Mo-MLV insertion region 1 (BMI1), and telomeric-repeat binding factor 1 (TRF1) foci

From: Heterogeneity in the kinetics of nuclear proteins and trajectories of substructures associated with heterochromatin

 

Average velocity (μm/s)

 

HP1β

BMI1

TRF1

Peripheral foci: control

0.034 ± 0.007

0.017 ± 0.003

0.024 ± 0.005

Peripheral foci: TSA

0.024 ± 0.011

0.012 ± 0.005

0.046 ± 0.012

Peripheral foci: actinomycin D

0.024 ± 0.003

0.016 ± 0.005

0.021 ± 0.015

Peripheral foci: vorinostat

0.020 ± 0.003

0.020 ± 0.007

0.026 ± 0.010

Central foci: control

0.036 ± 0.018

0.015 ± 0.003

0.021 ± 0.004

Central foci: TSA

0.028 ± 0.017

NA

0.050 ± 0.020

Central foci: actinomycin D

0.022 ± 0.003

0.013 ± 0.003

0.018 ± 0.003

Central foci: vorinostat

0.020 ± 0.004

0.017 ± 0.003

0.026 ± 0.010

Velocity mean: control

0.035 ± 0.012

0.016 ± 0.003

0.023 ± 0.005

Velocity mean: TSA

0.026 ± 0.014

-

0.047 ± 0.015

Velocity mean: actinomycin D

0.023 ± 0.003

0.015 ± 0.005

0.020 ± 0.010

Velocity mean: vorinostat

0.020 ± 0.004

0.018 ± 0.005

0.026 ± 0.010

  1. NA indicates that it was not possible to recognise centrally positioned foci using automated computer analysis.
  2. TSA = trichostatin A.