Heterochromatin protein 1β (HP1β), B lymphoma Mo-MLV insertion region 1 (BMI1), and telomeric-repeat binding factor 1 (TRF1) fluorescence recovery after vorinostat treatment. (a) Western blot analysis of H3K9 acetylation in MEFs and GFP-BMI-U2OS cells treated by vorinostat. (b) Fluorescence recovery of HP1β accumulated into foci or outside of foci in control and vorinostat-treated MEFs. (c) Fluorescence recovery after photobleaching (FRAP) data of BMI1 accumulated into PcG bodies or outside of PcG bodies in control and vorinostat-treated GFP-BMI-U2OS cells. (d) Fluorescence recovery of TRF1 associated with telomeres or dispersed in interchromatin space of control and vorinostat-treated MEFs.