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Figure 7 | Epigenetics & Chromatin

Figure 7

From: Enhancer-driven chromatin interactions during development promote escape from silencing by a long non-coding RNA

Figure 7

Model for escape from silencing by the Kcnq1 gene. Enhancer candidates, depicted as purple circles, become active upon binding tissue-specific transcription factors (TF); ncRNA, wavy lines. (A) Appearance of enhancer-specific transcription factors promotes a conformational change that sequesters the Kcnq1 promoter from the effects of Kcnq1ot1. (B) Factors binding in intron 1 of Kcnq1 act as a boundary for the Kcnq1ot1 ncRNA on the paternal allele, leaving it available for tissue-specific activation by enhancer-binding regulatory proteins.

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