IGF2BP1 promoter region is enriched with activating and silencing chromatin modifications. DNA recovered from ChIP experiments using anti-H3K4me3, anti-H3K27me3 and RNA polymerase II ChIP templates was genotyped by sequencing the IGF2BP1 promoter region containing sequence variant rs4794017 or rs9890278. Left: Enrichment of H3K4me3 (K4) and H3K27me3 (K27) in monoallelically (GM7007, GM6989), and biallelically (GM7057) expressing cell lines. The positions of informative SNPs rs479017 and rs9890278 are shown in Figure 1. Both activating and silencing marks are significantly enriched. Right: Sequences enriched by ChIP were excised and sequenced. The results show an association of both alleles with active and silent histone modifications at the IGF2BP1 promoter region independent of transcriptional status.