Genome-wide mapping of imprinted differentially methylated regions by DNA methylation profiling of human placentas from triploidies

Table 2 Eleven genes associated with candidate imprinted DMRs with confirmed monoallelic expression^a

Gene	DMR	SNP	Monoallelic expression, observed/total (%)	Monoallelic expression observed for reciprocal SNP^b	Matched expected parental origin, observed/total (%)^c
FAM50B	M	rs6597007	9/9 (100)	Y	5/5 (100)
DNMT1	M	rs16999593	1/1 (100)	-	1/1 (100)
MOV10L1	P	rs9617066	8/9 (89)	N	1/3 (33)
RHOBTB3	M	rs34896	3/4 (75)	Y	2/2 (100)
SNCB	M	rs2075667	3/4 (75)	N	NI
ARMC3	M	rs12259839	2/3 (67)	N	2/2 (100)
ST8SIA1	M	rs4762737	2/3 (67)	Y	0/1 (0)
ARHGAP4	P	rs2070097	1/2 (50)	-	NI
AIFM2	M	rs7908957	2/8 (25)	N	1/1 (100)
MCCC1	M	rs937652	2/8 (25)	Y	NI
LEP	P	rs2167270	1/15 (7)	-	1/1 (100)

^aDMR, differentially methylated region; SNP, single-nucleotide polymorphism; NI, not informative. ^bWhere both alleles of SNP were observed to be expressed among cases with monoallelic expression; this is impossible to determine if only one case showed monoallelic expression. ^cNumber of cases matching the expected parental origin of those cases informative with regard to determining parent of origin.

ISSN: 1756-8935