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Figure 1 | Epigenetics & Chromatin

Figure 1

From: Quantitative analysis of DNA methylation at all human imprinted regions reveals preservation of epigenetic stability in adult somatic tissue

Figure 1

Average methylation levels for germ-line differentially methylated regions (DMRs; n = 17 in each tissue). Box plots show median, inter-quartile range and maximum/minimum methylation (Bn = brain; Bt = breast; Co = colon; He = heart; Ki = kidney; Li = liver; Pl = placenta). (b) Average tissue methylation levels of somatic DMRs when analysed by parent-of-origin of the methylation. Each data point represents an individual C-phosphate guanine (CpG). Box plots show median, inter-quartile range and maximum/minimum methylation. (c) Intra-CpG variability of DMR methylation. The standard deviation of all CpGs assayed was calculated for each tissue (n = 8). Box plots show median, inter-quartile range and maximum/minimum methylation. Red = maternal germ-line DMRs; pink = maternal somatic DMRs; dark blue = paternal germ-line DMRs; light blue = paternal somatic DMRs; green = parent-of-origin and/or germ-line somatic status unknown.

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