Skip to main content
Figure 12 | Epigenetics & Chromatin

Figure 12

From: Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation

Figure 12

Lens-specific Brg1 targeting gives rise to a variety of ocular deficiencies. The cKO mutants were compared with Brg1flox/floxlittermates at postnatal day 1 (A-C) and postnatal day 7 (D-I). The mutant mice displayed ocular defects with various severities, including failure of cornea-eyelid separation (black arrows in B and C) or iris separation (E, I and H), aberrant lens and retina (B, C, E, F, and H) and even an absence of lens structure (I). Scale bar, 100 μm.

Back to article page