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Table 1 Dynamics of H3K4me3 and H3K27me3 profiles at imprinted genes between cell types.

From: Distinguishing epigenetic marks of developmental and imprinting regulation

 

ESCs

More differentiated cells

Gene

Expression

Histone modification

Expression

Histone modification

Cell type

Gatm

Absent

H3K4me3 H3K27me3

Present

H3K4me3

NPC

   

Present

H3K4me3 H3K27me3

MEF

Peg12

Absent

H3K4me3 H3K27me3

Present

H3K4me3

NPC+MEF

Tfpi2

Absent

H3K4me3 H3K27me3

Present

None

MEF

Ascl2

Absent

H3K4me3 H3K27me3

Absent

H3K4me3 H3K27me3

NPC+MEF

Calcr

Absent

H3K4me3 H3K27me3

Absent

H3K27me3

NPC+MEF

Kcnq1

Absent

H3K4me3 H3K27me3

Absent

H3K27me3

NPC+MEF

Rasgrf

Absent

H3K4me3 H3K27me3

Absent

H3K4me3 H3K27me3

NPC+MEF

Slc22a3

Absent

H3K4me3 H3K27me3

Absent

H3K27me3

NPC+MEF

Tfpi2

Absent

H3K4me3 H3K27me3

Absent

None

NPC

  1. Expression and histone modification profiles at developmentally repressed imprinted gene transcription start sites (TSSs) enriched with both H3K4me3 and H3K27me3 in mouse embryonic stem cells (ESCs) are detailed for neural progenitor cells (NPCs) and mouse embryonic fibroblasts (MEFs). The presence of these two marks in ESCs sometimes resolves to H3K4me3 in the more differentiated cell types at genes that become expressed (upper panel). Resolution (to H3K27me3) also occurs at some genes that do not change expression status and remain repressed (lower panel). The expression status and histone enrichment profile at the TSS of imprinted genes were identified using source data from Mikkelsen et al. [50].