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Table 1 Dynamics of H3K4me3 and H3K27me3 profiles at imprinted genes between cell types.

From: Distinguishing epigenetic marks of developmental and imprinting regulation

  ESCs More differentiated cells
Gene Expression Histone modification Expression Histone modification Cell type
Gatm Absent H3K4me3 H3K27me3 Present H3K4me3 NPC
    Present H3K4me3 H3K27me3 MEF
Peg12 Absent H3K4me3 H3K27me3 Present H3K4me3 NPC+MEF
Tfpi2 Absent H3K4me3 H3K27me3 Present None MEF
Ascl2 Absent H3K4me3 H3K27me3 Absent H3K4me3 H3K27me3 NPC+MEF
Calcr Absent H3K4me3 H3K27me3 Absent H3K27me3 NPC+MEF
Kcnq1 Absent H3K4me3 H3K27me3 Absent H3K27me3 NPC+MEF
Rasgrf Absent H3K4me3 H3K27me3 Absent H3K4me3 H3K27me3 NPC+MEF
Slc22a3 Absent H3K4me3 H3K27me3 Absent H3K27me3 NPC+MEF
Tfpi2 Absent H3K4me3 H3K27me3 Absent None NPC
  1. Expression and histone modification profiles at developmentally repressed imprinted gene transcription start sites (TSSs) enriched with both H3K4me3 and H3K27me3 in mouse embryonic stem cells (ESCs) are detailed for neural progenitor cells (NPCs) and mouse embryonic fibroblasts (MEFs). The presence of these two marks in ESCs sometimes resolves to H3K4me3 in the more differentiated cell types at genes that become expressed (upper panel). Resolution (to H3K27me3) also occurs at some genes that do not change expression status and remain repressed (lower panel). The expression status and histone enrichment profile at the TSS of imprinted genes were identified using source data from Mikkelsen et al. [50].