Figure 3
From: Distinguishing epigenetic marks of developmental and imprinting regulation
Histone modification patterns at imprinted genes across cell types. Histone modification profiles for H3K4me3 and H3K27me3 were analysed at transcription start sites of imprinted genes (n = 54) in mouse (A) embryonic stem cells (ESCs), (B) neural progenitor cells (NPCs) and (C) mouse embryonic fibroblasts (MEFs) using Mikkelsen et al. [50] whole-genome source data. The patterns of enrichment shown differ significantly across the three cell types (chi-square contingency test, P < 0.0005). Coenrichment of H3K4me3 and H3K27me3 is significantly higher at ESCs compared to NPCs (Yates' chi-square test, P < 0.01). A reduction from 41% in ESCs to 22% in MEFs is observed for this specific profile (Yates' chi-square test, P = 0.123).