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Figure 4 | Epigenetics & Chromatin

Figure 4

From: Lessons from genome-wide studies: an integrated definition of the coactivator function of histone acetyl transferases

Figure 4

HATs are corecruited at high frequency on their binding loci. Raw ChIP-seq data were extracted from [12, 13]. (a) Heat map showing colocalization frequency of all the five HATs, namely, MOF, p300, CBP, TIP60 and PCAF. Colors in the heat map reflect the colocalization frequency (Pearson correlation coefficient) of each pair of HAT (red means more frequently colocalized) over a 5-kb region surrounding the complete set of HAT binding sites. HATs were clustered along both axes based on the similarity in their colocalization with other HATs. (b) Co-occurrence of five HATs on CBP binding sites: Binding densities of PCAF, p300, MOF and TIP60 were clustered according to 10,360 CBP binding sites. In the clustering, each line represents a genomic location of a binding site with its surrounding ± 5-kb region. HAT binding sites were used as a reference to collect ChIP-seq tag densities over a 10-kb (± 5 kb) window in each HAT density map. This matrix was subjected to k-means clustering. The heat map representing the clustered density matrix is displayed.

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