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Figure 9 | Epigenetics & Chromatin

Figure 9

From: Menin and RNF20 recruitment is associated with dynamic histone modifications that regulate signal transducer and activator of transcription 1 (STAT1)-activated transcription of the interferon regulatory factor 1 gene (IRF1)

Figure 9

RNA polymerase II (Pol II) C-terminal domain (CTD) serine phosphorylation in signal transducer and activator of transcription 1 (STAT1)-activated interferon regulatory factor 1 gene ( IRF1 ) transcription is altered by RNF20 knockdown. Chromatin immunoprecipitation (ChIP) of stably selected 2fTGH cells expressing a non-silencing small hairpin (shRNA) or shRNA-RNF20 after induction with interferon (IFN)γ or uninduced using antibodies specific for total Pol II (a, b), the serine 5 phosphorylated CTD of Pol II (c, d) and the serine 2 phosphorylated CTD of Pol II (e, f). The same results are seen when the data are normalized to total Pol II.

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Epigenetics & Chromatin

ISSN: 1756-8935