Distribution of PCNA and GINS on extended chromatin fibers. (A) There is a high degree of overlap between PCNA (red signal), GINS (blue signal) and EdU tracks (green signal). (B) PCNA (red signal) and GINS (blue signal) coincide with bead-like structures that can also be seen on the DNA (green DNA stain). Two of the bead-like structures are marked with arrows. Bars ≅ 25 μm (≅ 400 kb; bottom right of each panel).