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Table 1 Correlations between pooled DNA methylation estimates and group averages assessed by individual sample analysis for CpG sites in each of the 9 genomic regions studied.

From: Bisulfite-based epityping on pooled genomic DNA provides an accurate estimate of average group DNA methylation

  FMR1 DRD4 SERT IGF2 GR ESR1 DAT1 MAOA AR ALL
Individual average vs pool estimate – replicate 1 0.95 0.93 0.93 0.93 0.98 - 0.95 0.89 0.94 0.95
Individual average vs pool estimate – replicate 2 0.81 0.97 0.88 0.95 0.90 0.81 0.92 0.72 1.00 0.95
Individual data – replicate 1 vs replicate 2 0.83 0.97 0.93 0.95 0.87 - 0.94 0.93 0.94 0.95
Individual average vs pool estimate – average across both replicates 0.95 0.95 0.95 0.93 0.98 0.81 0.97 0.86 0.98 0.95
  1. The overall correlation between the averaged individual data and the pooled estimate (0.95) is the same as that between replicates of the individual data (0.95).
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Epigenetics & Chromatin

ISSN: 1756-8935