Table 1 Post-translational modifications (PTMs) in polycomb group (PcG) biology
From: Talking to chromatin: post-translational modulation of polycomb group function
PcG protein | PTM | Interacting protein | Biological effect |
|---|---|---|---|
RNF2 (and RING1) | Ub | H2A (K119), H2A.Z | Transcriptional repression, X inactivation |
+ BMI1 | Â | Â | Histone H2A ubiquitylation |
+ phosphorylated MEL18 | Â | Â | Â |
+ PCGF1 | Â | Â | Â |
RNF2 | Ub (mono, poly) | - | Protein stability, |
BMI1 | Ub | - | Protein stability |
| Â | Â | CULLIN/SPOP3 | X inactivation |
RYBP | Ub | - | Histone H2A binding |
PRC1 | Ub | Geminin | Protein stability |
CBX4 | Sumo | CtBP | Â |
| Â | Â | Dnmt3a | Abolishes repression |
| Â | Â | HIPK2 | DNA damage response |
| Â | Â | SIP1 | Relieves E-cadherin repression |
| Â | Â | CBS | Inhibition CBS activity |
PCGF2 | Prevention of sumo | HSF2 | Decreased interaction during mitoses |
| Â | Â | RanGAP1 | Increased interaction during mitosis |
CBX4 | Sumo | - | - |
CtBP1 | Sumo | Â | Â |
SUZ12 | Sumo | PAISXβ | - |
EZH2 | Sumo | - | - |
BMI1 | Ph | Â | Chromatin dissociation |
CBX2 | Ph | - | Nuclear localization |
PCGF2/MEL18 | Ph | PKC | Blocks dimerization |
Esc (Drosophila) | Ph | Â | Homodimerization, complex formation/stabilization |
EED | Ph | Â | Homodimerization |
EZH2 | Ph | - | Histone H3 binding |
EZH1 | Ph | ZAP70 | Interaction |
RNF2 | Proteolytic cleavage | Caspases 3 and 9 | Apoptosis |
Ph (Drosophila)-PHC3 | O-GlcNAc | Sxc/Ogt | Repression: unknown |
RNF2 | Ac | - | Unknown |