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Table 1 Post-translational modifications (PTMs) in polycomb group (PcG) biology

From: Talking to chromatin: post-translational modulation of polycomb group function

PcG protein PTM Interacting protein Biological effect
RNF2 (and RING1) Ub H2A (K119), H2A.Z Transcriptional repression, X inactivation
+ BMI1    Histone H2A ubiquitylation
+ phosphorylated MEL18    
+ PCGF1    
RNF2 Ub (mono, poly) - Protein stability,
BMI1 Ub - Protein stability
   CULLIN/SPOP3 X inactivation
RYBP Ub - Histone H2A binding
PRC1 Ub Geminin Protein stability
CBX4 Sumo CtBP  
   Dnmt3a Abolishes repression
   HIPK2 DNA damage response
   SIP1 Relieves E-cadherin repression
   CBS Inhibition CBS activity
PCGF2 Prevention of sumo HSF2 Decreased interaction during mitoses
   RanGAP1 Increased interaction during mitosis
CBX4 Sumo - -
CtBP1 Sumo   
SUZ12 Sumo PAISXβ -
EZH2 Sumo - -
BMI1 Ph   Chromatin dissociation
CBX2 Ph - Nuclear localization
PCGF2/MEL18 Ph PKC Blocks dimerization
Esc (Drosophila) Ph   Homodimerization, complex formation/stabilization
EED Ph   Homodimerization
EZH2 Ph - Histone H3 binding
EZH1 Ph ZAP70 Interaction
RNF2 Proteolytic cleavage Caspases 3 and 9 Apoptosis
Ph (Drosophila)-PHC3 O-GlcNAc Sxc/Ogt Repression: unknown
RNF2 Ac - Unknown
  1. Listed are published biochemical connections between PcG and associated proteins; see text for details on functional relationships.
  2. Ph = phosphorylation; Su = sumoylation; Ub = ubiquitylation.