Figure 6
From: Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence
Senescence in mammalian cells is associated with a set number of γ-foci regardless of origin. (A) Numbers of γ-foci in the high population doublings or old cultures of the primary cell strains are arranged to show that the average total numbers of γ-foci per senescent or old cell are in the range 8–11, while the numbers of γ-foci found on the chromosome ends or on the arms are more variable. (B) The fractions of metaphase cells containing each range of γ-focal numbers are presented. Ranges of γ-focal numbers are taken to smooth the data.