Fig. 4

Differentially expressed phUMR and fhUMR related genes possess different chromatin features. A Average signals of histone modification mark around TSS and TES of differentially expressed genes between IDH mutant glioma and normal brain tissues. B Motif enrichment of these three hypermethylated regions with different transcriptional programs. P_up, hypermethylated regions in up-regulated phUMRs. P_down, hypermethylated regions in down-regulated phUMRs. F_down, hypermethylated regions of down-regulated fhUMRs. The color of transcription factors was apportioned by the effect to gene regulation. An asterisk indicates the transcription factor was previously reported to be methylation-sensitive. C The interaction of up-regulated phUMR-related transcription factors and PRC or HDAC related chromatin regulators. D Average signals of H3K4me3 and H3K27ac on partial Hyper and flanking UMR in up/down-regulated phUMRs. Average ChIP-seq signals were scaled into 2 kb for partial Hyper and flanking UMRs, respectively