Fig. 1
From: The SAGA histone acetyltransferase module targets SMC5/6 to specific genes
Strong genetic relation between the SMC5/6 and histone acetyltransferases. A Summary of significantly enriched GO categories for Biological processes of genes with genetic interactions with nse3-R254E (p < 0.005). B Negative log10 (p-values) evaluating the significance of the main GO Cellular component terms identified in the set of the 79 genes. Only the molecular complexes are shown. C Tetrad analysis of the heterozygous diploid fission yeast strains. The colony size of the nse3-R254E, Δgcn5 and nse3-R254E, Δada2 double mutant is significantly reduced (triangle). Single and double mutant alleles are indicated. D Ten-fold serial dilutions of the indicated strains were plated onto YES media and grown at 25 °C (control) or 37 °C. At least three independent drop tests have been carried out, and one of them is displayed as representative. The nse3-R254E (nse3/RE) mutation enhanced the sensitivity of the Δada2, Δada3 and Δgcn5 mutants to the higher temperature