From: Phthalates impact on the epigenetic factors contributed specifically by the father at fertilization
A. fivefold Paternal enriched and DBP responsive CRREWs | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
CRREW | CRREW class | Human sperm proteome | Paternally provided samples | DBP responsive samples | ||||||||
Visually full-length | RE | Mean abundance | DBP study arm | Visually full-length | RE | Baseline mean abundance | Crossover mean abundance | Crossback mean abundance | Movement with phthalate | |||
CUL2 | Chromatin remodeler cofactor | Yes | Full-length | chr10_35049683_35049765 | 73.34378112 | B1HB2 | Full-length | chr10_35071199_35071339a | 45.88953277 | 36.94494826 | 33.3796977 | Down—same |
chr10_35054434_35054539 | 90.27970798 | |||||||||||
chr10_35060874_35060968 | 124.36174959 | H1BH2 | Full-length | chr10_35031300_35031386 | 10.9300058 | 12.60999224 | 16.5514561 | Up—up | ||||
chr10_35062960_35063062 | 76.39002731 | |||||||||||
EFCAB6 | Chromatin remodeler cofactor | Yes | Full-length | chr22_43755766_43755832 | 47.99058386 | H1BH2 | Full-length | chr22_43808995_43809131b | 23.04421341 | 22.47121388 | 30.92004033 | Same—up |
FBRS | Chromatin remodeler cofactor | No | Full-length | chr16_30661180_30661215 | 139.16671978 | H1BH2 | Full-length | chr16_30665035_30665079a | 11.7002433 | 23.79308874 | 13.77795832 | Up—samec |
chr16_30661304_30661333 | 163.82992422 | |||||||||||
chr16_30662420_30662468 | 322.18875278 | chr16_30665306_30665401a | 15.91554696 | 33.45144483 | 17.72288399 | Up—samec | ||||||
chr16_30668772_30668979 | 38.16171231 | chr16_30665411_30665530b | 25.49395297 | 12.03010593 | 22.8260116 | Same -upc | ||||||
FUS | RNA interactor | Yes | Full-length | chr16_31189665_31189794 | 90.62018963 | B1HB2 | Full-length | chr16_31179681_31179790a | 17.54623506 | 8.059807977 | 9.112771891 | Down -same |
PHF10 | Chromatin remodeler cofactor | No | Full-length | chr6_169703905_169704088 | 56.77073068 | B1HB2 | Full-length | chr6_169712386_169712539a | 104.6714394 | 73.28088898 | 72.69274424 | Down—samec |
chr6_169717742_169717906b | 26.5058166 | 21.75793957 | 28.02153713 | Same -upc | ||||||||
H1BH2 | Full-length | chr6_169715708_169715857b | 46.4094406 | 41.91086488 | 25.73117816 | Same—downc | ||||||
chr6_169715266_169715305b | 9.913662168 | 3.92151334 | 12.24840542 | Same—upc | ||||||||
TP53BP1 | Reader | No | Full-length | chr15_43438324_43438416 | 60.10469689 | B1HB2 | Full-length (≥ 1 < 35 samples) | chr15_43491669_43491753a | 90.52982404 | 57.56060158 | 54.69346007 | Down—samec |
chr15_43474673_43474767a | 43.09581869 | 24.32817473 | 22.95757362 | Down—samec | ||||||||
chr15_43477593_43477759b | 19.25400217 | 11.49681526 | 12.46340685 | Same—upc |
B. twofold Paternally enriched and DBP responsive CRREWs | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
CRREW | CRREW class | Human sperm proteome | Paternally provided samples | Â | DBP responsive samples | |||||||
Visually full-length | RE | Mean abundance | DBP study arm | Visually full-length | RE | Baseline mean abundance | Crossover mean abundance | Crossback mean abundance | Movement with phthalate | |||
ACTB | Chromatin remodeling cofactor | No | Full-length (≥ 1 < 7 samples) | chr7_5529161_5529400 | 608.1603759 | B1HB2 | Fail | chr7_5527147_5527891a | 9.927226458 | 39.23923731 | 76.15182438 | Up—same |
chr7_5529535_5529663 | 160.4580747 | |||||||||||
ASXL3 | Chromatin remodeling cofactor | Yes | Full-length (≥ 1 < 7 samples) | chr18_33607594_33607676d | 126.69565505 | H1BH2 | Fail | chr18_33605537_33605658b | 49.02305219 | 57.68603612 | 29.20425494 | Same—down |
chr18_33607594_33607676b, d | 100.1024646 | 122.0676208 | 65.30310662 | |||||||||
ATXN7 | Chromatin remodeling cofactor | No | Full-length | chr3_63913157_63913225 | 23.23374838 | B1HB2 | Full-length (≥ 1 < 35 samples) | chr3_63971410_63971449a | 44.13861655 | 18.85341672 | 31.88951213 | Down—upc |
chr3_63952379_63952483 | 65.56893528 | chr3_63970990_63971199a | 28.29537781 | 16.13056589 | 15.78642347 | Down—samec | ||||||
chr3_63979915_63980167 | 65.82895373 | chr3_63970590_63970729a | 28.9651738 | 31.0349008 | 22.84394278 | |||||||
chr3_63982186_63982445 | 51.9743582 | |||||||||||
chr3_63982939_63983021 | 86.70154882 | H1BH2 | Full-length (≥ 1 < 55 samples) | chr3_63990176_63990374a | 15.20540033 | 23.06433484 | 18.39674764 | Up—same | ||||
chr3_63988059_63988324 | 86.65469577 | |||||||||||
chr3_63997621_63997687 | 20.627258 | |||||||||||
BRD2 | Reader | No | Full-length (≥ 1 < 7 samples) | chr6_32974462_32974765d | 167.2971302 | B1HB2 | Full-length (≥ 1 < 35 samples) | chr6_32974462_32974765a, d | 148.0520041 | 95.59297034 | 97.45927523 | Down—same |
chr6_32975384_32975521 | 244.581243 | |||||||||||
chr6_32976031_32976169 | 246.1430444 | |||||||||||
chr6_32976250_32976464 | 449.0591325 | |||||||||||
chr6_32978126_32978388 | 290.1415452 | chr6_32975021_32975112a | 88.41784757 | 53.73315186 | 53.689177 | |||||||
chr6_32979828_32980132 | 215.4520379 | |||||||||||
chr6_32980342_32980464 | 246.6401318 | |||||||||||
CBX8 | Reader | No | Full-length (≥ 1 < 7 samples) | chr17_79796250_79796315 | 109.1088811 | B1HB2 | Full-length (≥ 1 < 35 samples) | chr17_79796497_79796540a | 67.72774064 | 35.94307833 | 47.37031239 | Down—same |
CUL4A | Writer | Yes | Full-length (≥ 1 < 7 samples) | chr13_113245152_113245237d | 45.83401639 | H1BH2 | Fail | chr13_113245152_113245237b, d | 4.749607197 | 11.83695093 | 4.810742772 | Same—down |
DDX21 | RNA interactor | No | Full-length (≥ 1 < 7 samples) | chr10_68956077_68956312 | 45.59930818 | B1HB2 | Full-length (≥ 1 < 35 samples) | chr10_68973545_68973664a | 12.48308777 | 6.652350194 | 6.801472421 | Down—same |
chr10_68956128_68956312 | 58.23824687 | |||||||||||
chr10_68959806_68960249 | 27.30981821 | |||||||||||
DDX5 | Chromatin remodeling cofactor | No | Full-length | chr17_64499616_64500326 | 50.18733594 | H1BH2 | Full-length (≥ 1 < 55 samples) | chr17_64508057_64508199a | 18.07129807 | 31.49088399 | 21.44690173 | Up—same |
chr17_64502439_64502549 | 222.7743864 | |||||||||||
chr17_64502926_64503098 | 174.5232727 | |||||||||||
chr17_64504677_64504842 | 562.365823 | |||||||||||
EYA3 | Eraser | No | Full-length (≥ 1 < 7 samples) | chr1_28035544_28035680 | 40.65905966 | B1HB2 | Full-length (≥ 1 < 35 samples) | chr1_27989697_27989811a | 17.51387147 | 8.11829011 | 7.684114697 | Down—same |
chr1_28038839_28038905 | 71.9858758 | |||||||||||
chr1_28042571_28042650d | 82.19180154 | |||||||||||
chr1_28048383_28048426 | 55.11261243 | H1BH2 | Full-length (≥ 1 < 55 samples) | chr1_28042571_28042650b, d | 89.90445658 | 77.74204547 | 93.81864264 | Same—up | ||||
chr1_28057994_28058094 | 55.29632114 | |||||||||||
FBL | Writer | No | Full-length (≥ 1 < 7 samples) | chr19_39834668_39834813 | 60.41931957 | H1BH2 | Fail | chr19_39839859_39839958b | 18.59527254 | 27.37708055 | 9.213151401 | Same—down |
chr19_39840233_39840327 | 50.69038934 | |||||||||||
FOXP1 | Chromatin remodeling cofactor | No | Full-length (≥ 1 < 7 samples) | chr3_71041328_71041532d | 42.11617683 | H1BH2 | Fail | chr3_71041328_71041532b, d | 15.6839618 | 13.71369054 | 15.54280611 | Same—up |
FOXP4 | Chromatin remodeling cofactor | No | Fail | chr6_41587793_41587897 | 39.27112581 | B1HB2 | Fail | chr6_41591221_41591322a | 45.87619906 | 26.85038148 | 20.82985849 | Down—same |
chr6_41597176_41597242 | 144.390806 | |||||||||||
FTO | Eraser | No | Fail | chr16_53873786_53873865 | 21.75113943 | B1HB2 | Fail | chr16_54055231_54055250a | 69.62113525 | 20.61269425 | 18.47722558 | down—same |
GLYR1 | Reader | No | Fail | chr16_4822875_4822931 | 85.08743926 | H1BH2 | Fail | chr16_4845074_4845153b, d | 36.46972236 | 46.9269976 | 20.87481521 | Same—down |
chr16_4832774_4832912 | 56.47345151 | chr16_4846174_4846210b, d | 67.90414093 | 142.7455894 | 36.28550649 | |||||||
chr16_4845074_4845153d | 86.16449545 | chr16_4847228_4847342b | 18.02496292 | 35.7298856 | 10.55306118 | |||||||
chr16_4846174_4846210d | 214.7925019 | |||||||||||
GSK3B | Writer | No | Full-length | chr3_119863419_119863605 | 47.57577249 | B1HB2 | Full-length (≥ 1 < 35 samples) | chr3_119947268_119947351a, d | 9.469777621 | 4.330235615 | 3.812284788 | Down—same |
chr3_119876413_119876508 | 74.65344499 | |||||||||||
chr3_119905755_119905852 | 40.17183664 | |||||||||||
chr3_119947268_119947351d | 8.201198964 | |||||||||||
HDGF | Chromatin remodeling cofactor | No | Full-length (≥ 1 < 7 samples) | chr1_156742107_156743455 | 29.31885782 | B1HB2 | Full-length (≥ 1 < 35 samples) | chr1_156746941_156747070a | 38.46470389 | 21.80162743 | 33.42011021 | Down—up |
chr1_156745008_156745146 | 103.5140225 | |||||||||||
chr1_156745297_156745373 | 153.7851866 | |||||||||||
JAK2 | Writer | No | Fail | chr9_5044403_5044520 | 73.43333397 | B1HB2 | Fail | chr9_5093247_5093296a | 20.58490527 | 32.01820286 | 32.69512962 | Up—same |
chr9_5050686_5050831 | 107.4942939 | |||||||||||
chr9_5054563_5054884 | 130.4274597 | |||||||||||
chr9_5064883_5065040 | 25.21798197 | |||||||||||
chr9_5066678_5066789 | 24.52971222 | |||||||||||
chr9_5069022_5069208 | 21.28614607 | |||||||||||
chr9_5072492_5072626 | 14.53980654 | |||||||||||
JMJD1C | Eraser | No | Full-length | chr10_63215263_63215455 | 35.51650661 | B1HB2 | Full-length (≥ 1 < 35 samples) | chr10_63380318_63380482b | 17.4600717 | 19.05969651 | 18.90688543 | Same—up |
KDM3B | Eraser | No | Full-length (≥ 1 < 7 samples) | chr5_138381516_138381590 | 46.44162202 | B1HB2 | Fail | chr5_138381516_138381748a | 12.66998754 | 4.873031368 | 7.239254403 | Down—same |
METTL14 | Writer | No | Full-length | chr4_118689370_118689457 | 123.1705451 | B1HB2 | Full-length (≥ 1 < 35 samples) | chr4_118694436_118694526a, d | 83.51980054 | 46.03741119 | 51.4908201 | Down—same |
chr4_118691981_118692068 | 31.29652938 | |||||||||||
chr4_118694436_118694526d | 64.94446923 | |||||||||||
chr4_118703935_118704051 | 25.19397513 | |||||||||||
NCL | Chromatin remodeling cofactor | No | Full-length (≥ 1 < 7 samples) | chr2_231455378_231455397 | 102.5438988 | B1HB2 | Fail | chr2_231461540_231462017a | 5.236450253 | 20.29187093 | 12.3903226 | Up—same |
chr2_231455401_231455624 | 67.46658314 | |||||||||||
PBK | Writer | No | Fail | chr8_27833056_27833133 | 84.32665353 | B1HB2 | Fail | chr8_27822319_27822488a | 29.13220667 | 13.70207793 | 20.37717724 | Down—same |
PHC3 | Chromatin remodeling cofactor | No | Full-length (≥ 1 < 7 samples) | chr3_170136419_170136665 | 47.04021032 | B1HB2 | Fail | chr3_170136366_170136670b | 33.10320015 | 23.37991969 | 38.36697809 | Same—upc |
chr3_170125959_170126008b, e | 50.56724341 | 47.14446851 | 39.30243571 | Same—downc | ||||||||
chr3_170145423_170145521 | 43.83520446 | H1BH2 | Full-length (≥ 1 < 55 samples) | chr3_170125959_170126008b, e | 52.42505534 | 68.67472239 | 68.63626944 | Up—same | ||||
PIAS2 | Chromatin remodeling cofactor | Yes | Full-length (≥ 1 < 7 samples) | chr18_46829734_46829867 | 126.9338048 | H1BH2 | Full-length (≥ 1 < 55 samples) | chr18_46864164_46864248b | 22.18313576 | 34.11708408 | 15.93112434 | Same—down |
chr18_46890580_46891054 | 94.25493752 | |||||||||||
PKM | Writer | Yes | Full-length | chr15_72199029_72199756 | 209.0372187 | H1BH2 | Full-length (≥ 1 < 55 samples) | chr15_72218943_72219110b | 227.6530273 | 228.3467372 | 257.298983 | Same—up |
chr15_72202454_72202620 | 90.41567139 | |||||||||||
chr15_72203022_72203188 | 104.69183 | |||||||||||
chr15_72206728_72206880 | 186.5303306 | |||||||||||
chr15_72207127_72207277 | 114.0294777 | |||||||||||
chr15_72208621_72208891 | 435.9339603 | chr15_72221168_72221284b | 509.0236626 | 472.2128562 | 505.8016084 | |||||||
chr15_72209673_72209859 | 216.5984929 | |||||||||||
chr15_72210347_72210478 | 202.6510004 | |||||||||||
chr15_72217409_72217500 | 179.5251466 | |||||||||||
chr15_72218944_72219110 | 477.2075803 | |||||||||||
PRDM2 | Writer | No | Full-length (≥ 1 < 7 samples) | chr1_13731000_13731117 | 24.97864201 | B1HB2 | Fail | chr1_13732779_13732882a, d | 18.88791629 | 10.83481881 | 12.63840862 | Down—same |
chr1_13732779_13732882d | 37.83172965 | |||||||||||
RAD23B | Chromatin remodeling cofactor | No | Full-length | chr9_107300141_107300222 | 148.4985198 | B1HB2 | Full-length | chr9_107284227_107284516b | 135.0056956 | 108.3285612 | 102.4563633 | Same—up |
chr9_107302035_107302114 | 358.8938006 | |||||||||||
chr9_107306379_107306647 | 179.2885343 | |||||||||||
chr9_107318752_107318879 | 199.0418759 | |||||||||||
chr9_107321983_107322118 | 194.6844742 | |||||||||||
chr9_107323890_107324017 | 157.6747147 | |||||||||||
chr9_107324834_107325004 | 166.7800603 | |||||||||||
RARA | Chromatin remodeling cofactor | No | Full-length | chr17_40348316_40348464 | 264.966321 | H1BH2 | Full-length | chr17_40352566_40352785a | 16.33385634 | 26.58279889 | 13.14358956 | Up—same |
RNF168 | Writer | No | Full-length | chr3_196475231_196475312 | 48.87929838 | B1HB2 | Full-length | chr3_196499399_196499448a | 15.55914629 | 1.041898901 | 5.470952467 | Down—same |
chr3_196483770_196483891 | 241.4196715 | |||||||||||
chr3_196487399_196487578 | 559.0102154 | |||||||||||
chr3_196488607_196488683 | 281.9957217 | |||||||||||
RUVBL2 | Chromatin remodeling cofactor | No | Fail | chr19_49007302_49007368 | 59.04042657 | B1HB2 | Full-length (≥ 1 < 35 samples) | chr19_49014484_49014603b | 47.65755052 | 13.18043333 | 33.28447611 | Same—up |
chr19_49009776_49009882 | 35.42102967 | chr19_49011192_49011310b | 53.64749641 | 15.75904163 | 35.37293219 | |||||||
SET | Chromatin remodeling cofactor | No | Full-length (≥ 1 < 7 samples) | chr9_128691170_128691227 | 90.43894815 | H1BH2 | Full-length (≥ 1 < 55 samples) | chr9_128691837_128691856a | 156.10463 | 270.2214865 | 292.7547895 | Up—same |
chr9_128691858_128692000d | 72.31913227 | chr9_128691858_128692000a, d | 42.4648848 | 65.60493112 | 83.79094344 | |||||||
chr9_128693896_128694042 | 151.4424237 | |||||||||||
SF1 | RNA interactor | No | Full-length (≥ 1 < 7 samples) | chr11_64764606_64766155 | 26.12431153 | B1HB2 | Full-length (≥ 1 < 35 samples) | chr11_64769426_64769669a | 172.4290602 | 119.3861192 | 127.4741581 | Down—up |
chr11_64768106_64768286 | 481.6714801 | |||||||||||
chr11_64769022_64769129 | 287.9247696 | |||||||||||
chr11_64769223_64769338d | 347.3117268 | chr11_64769223_64769338a, d | 268.8584151 | 177.0664881 | 189.0964138 | |||||||
chr11_64769426_64769609 | 282.135809 | |||||||||||
chr11_64769964_64770053d | 189.6875959 | |||||||||||
chr11_64770256_64770408 | 285.8362465 | chr11_64769964_64770053b, d | 263.9851006 | 166.8656433 | 179.5980223 | |||||||
chr11_64773430_64773505 | 81.68394169 | |||||||||||
chr11_64776498_64776626 | 547.7503902 | |||||||||||
SMARCC1 | Chromatin remodeling cofactor | No | Full-length | chr3_47622207_47622341d | 96.91272122 | B1HB2 | Full-length | chr3_47622207_47622341a, d | 69.77555281 | 82.07564582 | 58.44521961 | Up—samec |
chr3_47635190_47635344d | 101.6629144 | chr3_47765620_47765659a | 109.4318057 | 60.44008143 | 77.52801638 | Down—samec | ||||||
chr3_47636022_47636136 | 211.0242123 | |||||||||||
chr3_47693241_47693300 | 161.5219186 | chr3_47635190_47635344b, d | 68.84826131 | 67.34912737 | 52.97551238 | Same—upc | ||||||
chr3_47701278_47701402 | 293.2391371 | |||||||||||
chr3_47706409_47706530 | 354.2425594 | chr3_47714415_47714490b | 79.49924111 | 65.37542844 | 51.74915032 | Same—downc | ||||||
chr3_47710683_47710808 | 239.6062289 | H1BH2 | Full-length | chr3_47638725_47638780a | 164.273275 | 199.1667454 | 152.0656841 | Up—same | ||||
chr3_47729025_47729094 | 108.5173138 | |||||||||||
chr3_47736034_47736126 | 318.1530337 | |||||||||||
chr3_47738029_47738110 | 551.5659307 | |||||||||||
chr3_47745908_47745993 | 250.9244825 | |||||||||||
chr3_47772817_47772936 | 90.04905398 | |||||||||||
TLE4 | Chromatin remodeling cofactor | No | Full-length | chr9_79573689_79573786 | 81.6334674 | B1HB2 | Full-length (≥ 1 < 35 samples) | chr9_79592157_79592236b | 467.4843202 | 474.343387 | 262.241103 | Same—down |
chr9_79652593_79652794 | 123.9598518 | |||||||||||
chr9_79704783_79704902 | 79.65856586 | |||||||||||
chr9_79705889_79705942 | 308.2412894 | |||||||||||
chr9_79706747_79706899 | 197.0445962 | |||||||||||
chr9_79708118_79708250 | 82.17201832 | |||||||||||
chr9_79722959_79723035 | 41.67603336 | |||||||||||
TRIM28 | Reader | No | Full-length (≥ 1 < 7 samples) | chr19_58547792_58547906 | 62.21120415 | B1HB2 | Full-length (≥ 1 < 35 samples) | chr19_58547135_58547511a | 17.9583947 | 11.84868698 | 12.65668525 | Down—same |
TRMT5 | Writer | No | Full-length | chr14_60975475_60976126d | 112.849635 | B1HB2 | Full-length | chr14_60975475_60976126a, d | 162.1052502 | 126.0231338 | 104.0717295 | Down—same |
chr14_60977514_60977638 | 181.1539029 | |||||||||||
chr14_60979231_60979886 | 238.7932734 | |||||||||||
YBX1 | RNA interactor | No | Full-length (≥ 1 < 7 samples) | chr1_42683403_42683466 | 112.849635 | H1BH2 | Full-length (≥ 1 < 55 samples) | chr1_42693490_42693523a | 15.04921986 | 16.15993097 | 18.42589961 | Up—same |
YWHAZ | Reader | No | Full-length | chr8_100916525_100920752 | 18.15976034 | B1HB2 | Full-length | chr8_100952850_100953057a | 7.347282187 | 9.551674351 | 6.886102163 | Up—same |
chr8_100924135_100924298 | 110.0538877 | |||||||||||
chr8_100924916_100925039 | 162.8023477 | |||||||||||
chr8_100951929_100952129 | 82.9444817 | |||||||||||
ZNF541 | Chromatin remodeling cofactor | No | Fail | chr19_47521479_47521654 | 7.42074551 | H1BH2 | Fail | chr19_47521854_47521994a | 20.03276583 | 10.73806747 | 14.37279423 | Down—same |