Fig. 1
From: Phthalates impact on the epigenetic factors contributed specifically by the father at fertilization
Study analysis design. A Briefly, dibutyl-phthalate (DBP) responsive RNA Element (RE)-containing RNAs (RE-RNAs) from each crossover–crossback segment and paternally provided set were identified. B Ontology was assessed by the Molecular Signature Database (MSigDB), and shared DBP responsive and paternally provided RE-RNAs determined. C Shared RE-RNAs were evaluated for presence in overlapping DBP responsive and paternally provided MSigDB enriched gene sets. CRREWs (chromatin remodeler cofactors, RNA interactors, Readers, Erasers, and Writers) RE-RNAs were identified, and their presence within overlapping DBP responsive and paternally provided MSigDB gene sets was assessed. D Gene network to visualize CRREW biological process interactions was generated. H1B; high-DBP (baseline visit) to background DBP (crossover visit), BH2; background DBP (crossover visit) to high-DBP (crossback visit), B1H; background DBP (baseline visit) to high-DBP (crossover visit), HB2; high-DBP (crossover visit) to background DBP (crossback visit)