Ageing-associated changes in DNA methylation in X and Y chromosomes

Kananen, Laura; Marttila, Saara

doi:10.1186/s13072-021-00407-6

Epigenetics & Chromatin

Table 2 Age-CpGs identified in four or more datasets in one sex (*only cg25140188 identified in all five datasets studied). In boldface, age-CpGs identified in both females and males (in two or more datasets for the other sex)

From: Ageing-associated changes in DNA methylation in X and Y chromosomes

	ID	Change with age	Gene (hg19)	Median β, males	Median β, females	CpG island
Y	cg27214488	Hyper	NLGN4Y	0.12		Shore
	cg20401549	Hypo	PRKY	0.07		Island
Male X	cg12737514	Hyper	*BCOR*	0.27	0.18	Island
	cg16140952	Hyper	CHRDL1	0.14		Shore
	cg21480420	Hyper	FAM70A	0.27		Shore
	cg06711837	Hyper	FGF13	0.15		Shore
	cg08783090	Hyper	GABRE	0.19		Island
	cg01222180	Hyper	GPR50	0.28		Island
	cg21672057	Hyper	KIAA2022	0.27		Island
	cg01289637	Hyper	LRCH2	0.09		Shore
	cg24823082	Hyper	MID1IP1	0.08		Shelf
	cg26481961	Hyper	*MXRA5*	0.19	0.17	Island
	cg00575851	Hyper	NCRNA00087	0.15		Shore
	cg12848223	Hyper	NRK	0.30		Shore
	cg14951132	Hyper	NRK	0.28		Island
	cg09935073	Hyper	PAK3	0.21		Open sea
	cg13775533	Hyper	PCDH19	0.37		Island
	cg05134041	Hyper	POU3F4	0.30		Shore
	cg09610569	Hyper	SLITRK2	0.11		Island
	cg10288278	Hyper	SLITRK4	0.30		Island
	cg01538344	Hyper	*TAF7L*	0.46	0.49	Island
	cg27326620	Hyper	ZC4H2	0.43		Open sea
	cg00525383	Hyper	ZIC3	0.23		Island
	cg03671371	Hyper		0.18		Island
	cg03718079	Hyper		0.18	0.35	Island
	cg17156570	Hyper		0.38	0.51	Shore
	cg03660876	Hypo	*ARHGAP6*	0.74	0.80	Open sea
	cg18422972	Hypo	*BCOR*	0.52	0.32	Island
	cg06758848	Hypo	FLNA	0.33		Island
	cg09761247	Hypo	IDS	0.19		Shore
	cg00168417	Hypo	*KIAA1210*	0.73	0.69	Shore
	cg03675615	Hypo	PAGE4	0.91		Open sea
	cg25863147	Hypo	*PDK3*	0.65	0.63	Shore
	cg09641151	Hypo	*PLXNA3*	0.67	0.44	Shore
	cg04532200	Hypo	*PLXNB3*	0.62	0.64	Shore
	cg19406003	Hypo	PLXNB3	0.42		Shelf
	cg18478786	Hypo	SLC25A5	0.11		Island
	cg21019788	Hypo	SUV39H1	0.28		Island
	cg06461462	Hypo	*TSC22D3*	0.66	0.75	Shore
	cg21900764	Hypo	UPF3B	0.09		Island
	cg19570406	Hypo	ZFP92	0.71		Shore
	cg25140188*	Hypo		0.44	0.46	Shelf
Female X	cg01538344	Hyper	*TAF7L*	0.46	0.49	Island
	cg08704539	Hyper	*TAF7L*	0.58	0.55	Island
	cg07811386	Hypo	CA5B		0.35	Open sea
	cg00168417	Hypo	*KIAA1210*	0.73	0.69	Shore
	cg05204193	Hypo	MAP3K7IP3		0.49	Shelf
	cg04532200	Hypo	*PLXNB3*	0.62	0.64	Shore
	cg02991082	Hypo	TSC22D3		0.10	Shore
	cg06461462	Hypo	*TSC22D3*	0.66	0.75	Shore
	cg17938879	Hypo			0.37	Open sea

Median methylation level across all datasets is given for both males and females

Back to article page

ISSN: 1756-8935

Contact us

Submission enquiries: journalsubmissions@springernature.com