Fig. 5
From: Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b
Kdm3a and Kdm3b are partially required for upregulation of genes following vitamin C treatment. a Kinetics of gene upregulation following vitamin C treatment. Log2 fold change in gene expression was evaluated by qRT-PCR at 12, 24, 48, and 72Â h following vitamin C treatment. b Fold change in gene expression following vitamin C treatment with siRNA knockdown of Kdm3a/3b or non-targeting control. Vitamin C-induced upregulation of genes is attenuated with Kdm3a/3b knockdown