Table 2 Biological pathways identified by pathway analysis of the differentially methylated genes in ATR-X
Biological pathway | Biosynthetic process | Nucleic acid metabolic process | Methylation process | ||
|---|---|---|---|---|---|
Number of genes in group | 14 | 12 | 3 | ||
Fisher’s exact enrichment score −ln(p value) | 5.9 | 4.6 | 4.6 | ||
Fisher’s exact right-tail p value | <0.01 | 0.01 | 0.01 | ||
Genes | DPPA4 | PPAP2C | ZNF274 | ATF7IP2 | PRDM9 |
ZNF718 | ZNF486 | CTDP1 | ZNF486 | BHMT2 | |
PRDM9 | ZNF274 | TFB2M | ZNF300 | TFB2M | |
BHMT2 | TFB2M | QKI | DPPA4 | ||
ZNF300 | ATF7IP2 | ZNF718 | ZNF248 | ||
QKI | CTDP1 | UBE2U | PRDM9 | ||
ZNF248 | ALG10B | ||||