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Table 1 Histone isoforms and post-translational modifications (PTMs) identified during mouse spermatogenesis and in mature mouse sperm

From: Comprehensive analysis of histone post-translational modifications in mouse and human male germ cells

Histone isoforms

H1

H1.0, H1.1, H1.2, H1.4, H1.5, H1.t, HILS

H2A

H2A.1, H2A.1h, H2A.2a, H2A.2b, H2A.2c, H2A.3, H2A.J, H2A.V, H2A.X, H2A.Z

H2B

tH2B, H2B.1b, H2B.1h, H2B.1k, H2B.1m, H2B.1p, H2B.2b, H2B.2e, H2B.3a, H2B.3b

H3

H3, H3.1, H3.3

H4

H4

Histone post-translational modifications

 M

 

  H1

K16ac, K21me1, S57ph, K63me

  H1t

M58ox, S59ph, K64me2, K65me3, K76ac, R80me1, S140ph, K142ac, K145me1/3, T146ph, K147cr, K150ac, K151me1, K170ac, S177ph, K190me1, K192cr, M193ox, M195ox

  H2A

K5ac, K9ac, R35me1, K36ac, K74ac, R77me1, K125ac, K129me1

  H2AV/Z

K11cr, K11me2, K13cr, K13me2/3, K15ac, K15me3, S18ph, R19me1

  H2B

S4phb, K5ac, K5me1/2/3, S6ph, K11ac, K11cr, K11me1/2/3, K12ac, K12cr, K12me1/3, S14ph, K15ac, K15cr, K15me1/3, K16ac, K16cr, K16me1/3, K20ac, K24me3, K27me1, K27cr, K28me3, R29me1, K120me2, S123ph, K125me3

  tH2B

K6ac, K6cr, K6me1/3, K12ac, K12me1/3, K13cr, K13me1, K16ac, K16cr, K16me1/3, K17cr, K21ac, K24ac, K25me1

  H3

K4me1, K9me1/2/3, K14ac, K23me1/2, R26me, K27me1/2/3, K36ac, K36me1/2/3, K37me3, R53me1, K56ac, K79me1/2, M120ox

  H4

K5ac, K8ac, K12ac, K12me1, K12cr, K16ac, K16cr, R17me1, K20me1/2/3, K31ac, R35me1, M84ox, K91ac, R92me1

 RS

  H1

K16ac, S40ph, S57ph, K63me1

  H1t

M58ox, S59ph, K64me1/3, K76ac, R80me1, S140ph, K142ac, S144ph, K145me2/3, T146ph, K147ac, K147cr, K147me1, K150ac, K170ac, S177ph, M193ox, M195ox

  H2A

K5ac, R35me1, K36ac, K125ac, K129me1

  H2Z

K4ac, K11cr, K11me2, K13cr, K13me2, T14ph, K15me3, K15ac, R19me1

  H2B

S4ph b, K5ac, K5cr, K5me1/2/3, R5me a, K11ac, K11me1/3, K12ac, K12cr, K12me1/2/3, S14ph, K15ac, K15cr, K15me1/2/3, K16ac, K16cr, K16me1/3, K20ac, K24me3, K27cr, K28ac, K28cr, R29me1, K120me2, S123ph, K125me3

  tH2B

K6ac, K6me1, S11ph, K12me,1 K13ac, K13me1/3, K16ac, K16me1, K16cr, K17me1, K21ac

  H3

K4me1, K9me1/2/3, K14ac, K18me1/2, K23me1/2, R26me1, K27me1/2/3, K36me1/2/3, R53me1, K56ac, K79me1/2, M120ox

  H4

K5ac, K8ac, K12ac, K12me1, K16ac, K16me1, R17me1, K20me1/2/3, K31ac, R35me1, M84ox, K91ac, R92me1

 ES

  H1

K16ac, S57ph, K63me1, K74ac, R78me1

  H1t

M58ox, K76ac, R80me1, S140ph, K142ac, T146ph, K147me1, K147cr, K151me3, K170ac, M193ox, M195ox

  H2A

K5ac, K74ac, K75ac, R77me1

  H2AZ

K11me2, K13me2, T14ph, K15ac, K15me3, R19me1

  H2B

K5ac, K5cr, K5me1, K11ac, K11me1/2, K12me1/3, K15cr, K15me1, K16ac, K16cr, K16me1, K120me2, S123ph, K125me3

  tH2B

K6ac, K12me3, K13me1, K16me1, K17me1, K21ac

  H3

K9me1/2/3, K14ac, K23ac, K23me1, R26me1, K27me1/2/3, K36ac, K36me1/2, K37me3, R53me1, K56ac, K79me1/2, M120ox

  H4

K5ac, K8ac, K12ac, K16ac, K20me1/2/3, M84ox, K91ac, R92me1

 Sp

 

  H1

K19ac c, K25me1, K27me1 c, M30ox c

  H2A

M51ox, K74ac, K75ac, R77me1

  H2AV/Z

K7ac, K11cr, K11me2, K13cr, K13me1/2, T14ph, K15cr, K15me1/3, S18ph, K74me3, K77cr, K79cr

  H2B

K5ac, K5cr, K5me1/2, S6ph, K11ac, K11me1/3, K12ac, K12cr, K12me1/3, S14ph, K15ac, K15cr, K15me1/3, K16ac, K16cr, K16me1, K24me3, K27cr, K27me1, K28ac, K28cr, K28me3, R29me1, K120me2, S123ph, K125me3

  H3

K9me1/2/3, K14ac, K23ac, R26me1, K27me1/2/3, K36ac, K36me1/2, K37me3, K37cr, R40me1, R53me1, K56ac, K79me1/2, M120ox

  H4

K5ac, K8ac, K12ac, K16ac, R17me1, K20me1/2/3, M84ox, K91ac, K91cr, R92me1

  1. Includes PTMs identified on any isoform except those with modified, non-conserved amino acid residues (H1t, H2AV, H2AZ, tH2B). Underlined PTMs do not appear in the subsequent cell stage, and italicized PTMs were not present in the previous cell stage
  2. aR5 is present only on the H2B3A isoform
  3. bS4 is present only on H2B3B isoform
  4. cPresent only on H1.0 isoform
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Epigenetics & Chromatin

ISSN: 1756-8935