Fig. 1

Hox protein binding and chromatin accessibility in Kc167 cells. a Comparison of binding profiles of the three Bithorax complex Hox proteins (Ubx, Abd-A and Abd-B) and DNase1 accessibility in Kc167 cells. Examples of Abd-B specific peaks are highlighted in grey. b Venn diagrams showing overlap analysis of binding peaks. Hox peaks are q-value 1e−10 and DNase1 peaks are q-value 1e−2. Percentage overlap is indicated. The overlap of Abd-A and Ubx is reinforced by stringent versus relaxed analysis (i.e. overlap of q-value 1e−10 peaks with q-value 1e−2 peaks); for example, Abd-A stringent almost completely overlaps Ubx relaxed (99.6 %), whereas Abd-B stringent only has 75 % overlap with Ubx relaxed. c Scatter plots showing Pearson’s correlations between the Hox protein binding profiles based on binding score per 1 kb window. The Ubx and Abd-A profiles are highly correlated, while the correlations with Abd-B are lower and the binding scores more scattered