Fig. 6
From: The histone chaperone DAXX maintains the structural organization of heterochromatin domains
Speculative cartoon model of DAXX-dependent nuclear organization. The DAXX/ATRX complex selectively deposits H3.3 on the periphery of H3K9me3-enriched chromatin domains (top panel). This DAXX-dependent H3.3K9me3 epigenetic profile may index specific genomic regions, thereby marking the boundaries of and establishing pericentric constitutive heterochromatin domains (non-nucleolar and perinucleolar). In the absence of DAXX (middle panel), an aberrant pattern of H3.3 deposition may result in the misappropriation of heterochromatin boundaries between H3K9me3-enriched chromatin and the chromatin surrounding these regions. Consequently, ectopic domains of compact chromatin may be formed and the structural integrity of nucleoli may be compromised