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Figure 7 | Epigenetics & Chromatin

Figure 7

From: Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility

Figure 7

Combinations of epigenetic features and their association with enhancer activity. (A) Each row of the diagram shows the features and activity results for 1 of the 273 tested DNA segments. The presence or absence of the 11 epigenetic features is represented by grey and white, respectively. The tested segments were organized into clusters by DBSCAN [69] using the binary representation of the epigenetic features. Each tested DNA segment is also categorized by activity in the transient transfection assay, denoted by a colored entry in the last three rows (red = active, pink = threshold, blue = inactive). Success rates (B) and activities (C) in enhancer assays on 273 DNA segments in each cluster formed by DBSCAN. (D) Power of SMAD1 and TAL1 binding to identify enhancers.

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Epigenetics & Chromatin

ISSN: 1756-8935