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Table 5 Ectopic CENP-A is enriched at DNase I hypersensitive (DHS) sites and transcription factor binding sites

From: CENP-A nucleosomes localize to transcription factor hotspots and subtelomeric sites in human cancer cells

CENP-A hotspots a

Normal colon

%

HeLa

%

SW480

%

DNase clusters b

273

60.80

247

26.22

1292

45.44

Txn Factor ChIP c

285

63.47

255

27.07

1361

47.87

  1. Comparative analysis of aCENP-A hotspots derived from normal colon, HeLa and SW480 cells compared to ENCODE data aggregates reveal a significant fraction of sites overlap with ENCODE bDNase I clusters and ctranscription factor binding sites in the genome. Each column shows overlap in terms of number of sites or % of total CENP-A sites.
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Epigenetics & Chromatin

ISSN: 1756-8935