Figure 4

Intron-containing genes show a marked shift in the occupancy of RNAPII Ser 5-P in the absence of Chd1. The top 500 genes with the highest transcription rate (TR) as measured by RNAPII Ser-5 P occupancy[35] were defined as the high TR genes. Upper and lower panels show average profiles of RNAPII Ser 5-P and Ser 2-P occupancies, respectively. The left panels show the high TR gene set without any intron-containing genes (n =382), whereas the right panels show only the intron-containing genes from among the high TR genes (n =118). The shaded bands represent the 95% confidence interval of the data.