Volume 6 Supplement 1

Epigenetics and Chromatin: Interactions and processes

Open Access

Kinetic control of nucleosome displacement by ISWI/ACF chromatin remodelers

  • Ana-Maria Florescu1, 2,
  • Helmut Schiessel3 and
  • Ralf Blossey2
Epigenetics & Chromatin20136(Suppl 1):P7

DOI: 10.1186/1756-8935-6-S1-P7

Published: 18 March 2013

Chromatin structure is dynamically organized by chromatin remodelers, motor protein complexes which move and remove nucleosomes. The regulation of remodeler action has recently been proposed to underlie a kinetic proofreading scheme which combines the recognition of histone-tail states and the ATP-dependent loosening of DNA around nucleosomes. Members of the ISWI-family of remodelers additionally recognize linker length between nucleosomes. Here, we show that the additional proofreading step involving linker length alone is sufficient to promote the formation of regular arrays of nucleosomes. ATP-dependent remodeling by bidirectional motors is shown to reinforce positioning as compared to statistical positioning.

Authors’ Affiliations

Max-Planck-Institute for the Physics of Complex Systems
Interdisciplinary Research Institute, Université des Sciences et des Technologies de Lille (USTL), CNRS USR 3078
Lorentz Institut voor de theoretische natuurkunde, Universiteit Leiden


© Florescu et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.