Figure 5From: Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k arrayEnrichment of GO terms with nearest genes of tDMRs. Different colours represent the distinct major classes. Notice the difference in major classes between genes enriched with tDMRs that have a CGI or CGI flanking region and those which do not. When no CGI is present, tissue-specific genes are observed, while when there is a CGI present, the genes enriched with a tDMR are more often involved in embryonic developmental processes and gene regulation genes. Genes with a differentially methylated shelf overlapping with the proximal promoter, were associated with developmental -, housekeeping -, and tissue-specific GO terms. CGI, CpG island; GO, gene ontology; tDMR, tissue-specific differentially methylated region.Back to article page