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Figure 8 | Epigenetics & Chromatin

Figure 8

From: Heterogeneity in the kinetics of nuclear proteins and trajectories of substructures associated with heterochromatin

Figure 8

Telomeric-repeat binding factor 1 (TRF1) dynamics at telomeric regions and nuclear regions away from telomeres. Fluorescence recovery time after photobleaching was studied for TRF1 protein accumulated in telomeric clusters (triangle) and away from telomeres (black dots). The analysis was performed in (a) control MEFs; (b) TSA-treated MEFs and (c) after actinomycin D treatment. Additional comparison was performed for TRF1 in control (black dots), TSA-treated (triangles), and actinomycin D-stimulated (squares) cells in nuclear regions (d) absent of telomeric clusters (unbounded protein), and (e) for TRF1 foci associated with clusters of telomeres.

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Epigenetics & Chromatin

ISSN: 1756-8935