Epigenetics & Chromatin is affiliated with the International Society for Molecular and Clinical Epigenetics (isMOCLEP). isMOCLEP is open to all those interested in the wide spectrum of epigenetic research, from molecular to clinical aspects. isMOCLEP community welcomes academic researchers, early career scientists, companies, policy makers, and beyond.
Multiple distinct domains of human XIST are required to coordinate gene silencing and subsequent heterochromatin formation
Mammalian dosage compensation is achieved by the inactivation of one X chromosome in XX individuals. In eutheria this process is initiated early in development by the long non-coding RNA XIST. Studies of the i...