Figure 7
From: Histone deacetylases 1 and 2 maintain S-phase chromatin and DNA replication fork progression
SMARCA5 associates with candidate replication origins during S-phase. Serum-starved (SS, 0 h) NIH3T3 cells were released into S-phase in the presence of DMSO or 3 μM 898. SMARCA5 occupancy at α-globin (early replicating origin), pancreatic amylase (mid-late replicating) and β-globin (late replicating) in synchronous NIH3T3 cells were determined using chromatin immunoprecipitation (ChIP) assays. Average fold enrichment for SMARCA5 relative to input from two independent experiments is shown.